Publications

A cell atlas of thoracic aortic perivascular adipose tissue: a focus on mechanotransducers.. Am J Physiol Heart Circ Physiol 5(326): H1252-H1265. Thompson, Janice M; Watts, Stephanie W; Terrian, Leah; Contreras, G Andres; Rockwell, Cheryl; Rendon, C Javier; Wabel, Emma; Lockwood, Lizbeth; Bhattacharya, Sudin; Nault, Rance. 2024 May 01.
KEAP1-Mutant Lung Cancers Weaken Anti-Tumor Immunity and Promote an M2-like Macrophage Phenotype.. Int J Mol Sci 6(25): . Occhiuto, Christopher J; Liby, Karen T. 2024 Mar 20.
Impact of soluble epoxide hydrolase inhibition on silica-induced pulmonary fibrosis, ectopic lymphoid neogenesis, and autoantibody production in lupus-prone mice.. Inhal Toxicol 45846(36): 442-460. McDonald, Olivia F; Wagner, James G; Lewandowski, Ryan P; Heine, Lauren K; Estrada, Vanessa; Pourmand, Elham; Singhal, Megha; Harkema, Jack R; Lee, Kin Sing Stephen; Pestka, James J. 2024.
Transcriptomic profiling of early synucleinopathy in rats induced with preformed fibrils.. NPJ Parkinsons Dis 1(10): 7. Patterson, Joseph R; Kochmanski, Joseph; Stoll, Anna C; Kubik, Michael; Kemp, Christopher J; Duffy, Megan F; Thompson, Kajene; Howe, Jacob W; Cole-Strauss, Allyson; Kuhn, Nathan C; Miller, Kathryn M; Nelson, Seth; Onyekpe, Christopher U; Beck, John S; Counts, Scott E; Bernstein, Alison I; Steece-Collier, Kathy; Luk, Kelvin C; Sortwell, Caryl E. 2024 Jan 03.
Dietary docosahexaenoic acid supplementation inhibits acute pulmonary transcriptional and autoantibody responses to a single crystalline silica exposure in lupus-prone mice.. Front Immunol (15): 1275265. Chauhan, Preeti S; Benninghoff, Abby D; Favor, Olivia K; Wagner, James G; Lewandowski, Ryan P; Rajasinghe, Lichchavi D; Li, Quan-Zhen; Harkema, Jack R; Pestka, James J. 2024.
The Role of Endoplasmic Reticulum Stress on Reducing Recombinant Protein Production in Mammalian Cells.. Biochem Eng J (210): . Splichal, R Chauncey; Chen, Kevin; Walton, S Patrick; Chan, Christina. 2024 Oct.
Alpha-synuclein inclusion responsive microglia are resistant to CSF1R inhibition.. J Neuroinflammation 1(21): 108. Stoll, Anna C; Kemp, Christopher J; Patterson, Joseph R; Kubik, Michael; Kuhn, Nathan; Benskey, Matthew; Duffy, Megan F; Luk, Kelvin C; Sortwell, Caryl E. 2024 Apr 25.

Exploring structural effects in a new class of NRF2 inhibitors.. RSC Med Chem 1(14): 74-84. Hou, Zhilin; Lockwood, Lizbeth; Zhang, Di; Occhiuto, Christopher J; Mo, Linqing; Aldrich, Kelly E; Stoub, Hayden E; Gallo, Kathleen A; Liby, Karen T; Odom, Aaron L. 2023 Jan 25.
A genetic selection for Mycobacterium smegmatis mutants tolerant to killing by sodium citrate defines a combined role for cation homeostasis and osmotic stress in cell death.. mSphere 5(8): e0035823. Williams, John T; Baker, Jacob J; Zheng, Huiqing; Dechow, Shelby J; Fallon, Jared; Murto, Megan; Albrecht, Veronica J; Gilliland, Haleigh N; Olive, Andrew J; Abramovitch, Robert B. 2023 Oct 24.
Discovery and characterization of antimycobacterial nitro-containing compounds with distinct mechanisms of action and in vivo efficacy.. Antimicrob Agents Chemother 9(67): e0047423. Eke, Ifeanyichukwu E; Williams, John T; Haiderer, Elizabeth R; Albrecht, Veronica J; Murdoch, Heather M; Abdalla, Bassel J; Abramovitch, Robert B. 2023 Sep 19.
The impact of poor metabolic health on aggressive breast cancer: adipose tissue and tumor metabolism.. Front Endocrinol (Lausanne) (14): 1217875. Sankofi, Barbara Mensah; Valencia-Rincón, Estefania; Sekhri, Malika; Ponton-Almodovar, Adriana L; Bernard, Jamie J; Wellberg, Elizabeth A. 2023.
Lipidome modulation by dietary omega-3 polyunsaturated fatty acid supplementation or selective soluble epoxide hydrolase inhibition suppresses rough LPS-accelerated glomerulonephritis in lupus-prone mice.. Front Immunol (14): 1124910. Favor, Olivia K; Chauhan, Preeti S; Pourmand, Elham; Edwards, Angel M; Wagner, James G; Lewandowski, Ryan P; Heine, Lauren K; Harkema, Jack R; Lee, Kin Sing Stephen; Pestka, James J. 2023.
The Triterpenoid CDDO-Methyl Ester Redirects Macrophage Polarization and Reduces Lung Tumor Burden in a Nrf2-Dependent Manner.. Antioxidants (Basel) 1(12): . Moerland, Jessica A; Leal, Ana S; Lockwood, Beth; Demireva, Elena Y; Xie, Huirong; Krieger-Burke, Teresa; Liby, Karen T. 2023 Jan 03.
Crystalline silica-induced proinflammatory eicosanoid storm in novel alveolar macrophage model quelled by docosahexaenoic acid supplementation.. Front Immunol (14): 1274147. Favor, Olivia K; Rajasinghe, Lichchavi D; Wierenga, Kathryn A; Maddipati, Krishna R; Lee, Kin Sing Stephen; Olive, Andrew J; Pestka, James J. 2023.
The Multi-Faceted Consequences of NRF2 Activation throughout Carcinogenesis.. Mol Cells 3(46): 176-186. Occhiuto, Christopher J; Moerland, Jessica A; Leal, Ana S; Gallo, Kathleen A; Liby, Karen T. 2023 Mar 31.
A Genome-Wide Screen in Macrophages Defines Host Genes Regulating the Uptake of Mycobacterium abscessus.. mSphere 2(8): e0066322. Gilliland, Haleigh N; Beckman, Olivia K; Olive, Andrew J. 2023 Apr 20.
Microglial depletion does not impact alpha-synuclein aggregation or nigrostriatal degeneration in the rat preformed fibril model.. Res Sq (): . Stoll, Anna C; Kemp, Christopher J; Patterson, Joseph R; Kubik, Michael; Kuhn, Nathan; Benskey, Matthew; Duffy, Megan F; Luk, Kelvin; Sortwell, Caryl E. 2023 May 04.
Dihydroxy-Metabolites of Dihomo-γ-linolenic Acid Drive Ferroptosis-Mediated Neurodegeneration.. ACS Cent Sci 5(9): 870-882. Sarparast, Morteza; Pourmand, Elham; Hinman, Jennifer; Vonarx, Derek; Reason, Tommy; Zhang, Fan; Paithankar, Shreya; Chen, Bin; Borhan, Babak; Watts, Jennifer L; Alan, Jamie; Lee, Kin Sing Stephen. 2023 May 24.
Total Synthesis of Nagelamide W.. J Org Chem 13(88): 9306-9312. George, Dare E; Tepe, Jetze J. 2023 Jul 07.

Developmental deltamethrin: Sex-specific hippocampal effects in Sprague Dawley rats.. Curr Res Toxicol (3): 100093. Pitzer, Emily M; Sugimoto, Chiho; Regan, Samantha L; Gudelsky, Gary A; Williams, Michael T; Vorhees, Charles V. 2022.
Adenoviral delivery of an immunomodulatory protein to the tumor microenvironment controls tumor growth.. Mol Ther Oncolytics (24): 180-193. O'Connell, Patrick; Blake, Maja K; Pepelyayeva, Yuliya; Hyslop, Sean; Godbehere, Sarah; Angarita, Ariana M; Pereira-Hicks, Cristiane; Amalfitano, Andrea; Aldhamen, Yasser A. 2022 Mar 17.
5xFAD mice do not have myenteric amyloidosis, dysregulation of neuromuscular transmission or gastrointestinal dysmotility.. Neurogastroenterol Motil 12(34): e14439. Yelleswarapu, Narayana Krishna; Masino, Marlene; Henderson, Skye; Fernandes, Roxanne; Swain, Greg; Galligan, James J; Xu, Hui. 2022 Dec.
Developmental or adult-onset deletion of neurotensin receptor-1 from dopamine neurons differentially reduces body weight.. Front Neurosci (16): 874316. Perez-Bonilla, Patricia; Ramirez-Virella, Jariel; Menon, Pooja; Troyano-Rodriguez, Eva; Arriaga, Sydney K; Makela, Anna; Bugescu, Raluca; Beckstead, Michael J; Leinninger, Gina M. 2022.
SLAMF7 modulates B cells and adaptive immunity to regulate susceptibility to CNS autoimmunity.. J Neuroinflammation 1(19): 241. O'Connell, Patrick; Blake, Maja K; Godbehere, Sarah; Amalfitano, Andrea; Aldhamen, Yasser A. 2022 Oct 03.
Fundamentals to therapeutics: Epigenetic modulation of CD8+ T Cell exhaustion in the tumor microenvironment.. Front Cell Dev Biol (10): 1082195. Blake, Maja K; O'Connell, Patrick; Aldhamen, Yasser A. 2022.
Sc(OTf)3-Mediated One-Pot Synthesis of 3,4-Disubstituted 1H-Pyrazoles and 3,5-Disubstituted Pyridines from Hydrazine or Ammonia with Epoxides.. J Org Chem 24(87): 16820-16828. Mehedi, Md Shafaat Al; George, Dare E; Tepe, Jetze J. 2022 Dec 16.
The rexinoid V-125 reduces tumor growth in preclinical models of breast and lung cancer.. Sci Rep 1(12): 293. Reich, Lyndsey A; Moerland, Jessica A; Leal, Ana S; Zhang, Di; Carapellucci, Sarah; Lockwood, Beth; Jurutka, Peter W; Marshall, Pamela A; Wagner, Carl E; Liby, Karen T. 2022 Jan 07.
The Complicated Role of Nuclear Factor Erythroid-Derived 2-Like 2 in Allergy and Asthma.. Drug Metab Dispos 4(50): 500-507. Rockwell, Cheryl E; Jin, Yining; Boss, Allison P; Kaiser, Luca M; Awali, Saamera. 2022 Apr.
ERAP1 is a critical regulator of inflammasome-mediated proinflammatory and ER stress responses.. BMC Immunol 1(23): 9. Blake, Maja K; O'Connell, Patrick; Pepelyayeva, Yuliya; Godbehere, Sarah; Aldhamen, Yasser A; Amalfitano, Andrea. 2022 Mar 04.
Beta2-adrenoreceptor agonist clenbuterol produces transient decreases in alpha-synuclein mRNA but no long-term reduction in protein.. NPJ Parkinsons Dis 1(8): 61. Patterson, Joseph R; Hirst, Warren D; Howe, Jacob W; Russell, Christopher P; Cole-Strauss, Allyson; Kemp, Christopher J; Duffy, Megan F; Lamp, Jared; Umstead, Andrew; Kubik, Michael; Stoll, Anna C; Vega, Irving E; Steece-Collier, Kathy; Chen, Yi; Campbell, Anne C; Nezich, Catherine L; Glajch, Kelly E; Sortwell, Caryl E. 2022 May 24.
Dopaminergic Positron Emission Tomography Imaging in the Alpha-Synuclein Preformed Fibril Model Reveals Similarities to Early Parkinson's Disease.. Mov Disord 8(37): 1739-1748. Sossi, Vesna; Patterson, Joseph R; McCormick, Siobhan; Kemp, Christopher J; Miller, Kathryn M; Stoll, Anna C; Kuhn, Nathan; Kubik, Michael; Kochmanski, Joseph; Luk, Kelvin C; Sortwell, Caryl E. 2022 Aug.

Activation of ventral tegmental area neurotensin Receptor-1 neurons promotes weight loss.. Neuropharmacology (195): 108639. Perez-Bonilla, Patricia; Santiago-Colon, Krystal; Matasovsky, Jillian; Ramirez-Virella, Jariel; Khan, Rabail; Garver, Hannah; Fink, Gregory; Dorrance, Anne M; Leinninger, Gina M. 2021 Sep 01.
Advances in Proteasome Enhancement by Small Molecules.. Biomolecules 12(11): . George, Dare E; Tepe, Jetze J. 2021 Nov 30.
Calmodulin acetylation: A modification to remember.. J Biol Chem 4(297): 101273. Sugimoto, Chiho; Robison, A J. 2021 10.

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